Journal article
Role of Dopamine 2 Receptor in Impaired Drug-Cue Extinction in Adolescent Rats
IC Zbukvic, DE Ganella, CJ Perry, HB Madsen, CR Bye, AJ Lawrence, JH Kim
Cerebral Cortex | Published : 2016
Abstract
Adolescent drug users display resistance to treatment such as cue exposure therapy (CET), as well as increased liability to relapse. The basis of CET is extinction learning, which involves dopamine signaling in the medial prefrontal cortex (mPFC). This system undergoes dramatic alterations during adolescence. Therefore, we investigated extinction of a cocaine-associated cue in adolescent and adult rats. While cocaine self-administration and lever-alone extinction were not different between the two ages, we observed that cue extinction reduced cue-induced reinstatement in adult but not adolescent rats. Infusion of the selective dopamine 2 receptor (D2R)-like agonist quinpirole into the infral..
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Awarded by Australian Research Council
Funding Acknowledgements
This work was supported by a project grant (grant number APP1063140) from the National Health and Medical Research Council (NHMRC) of Australia awarded to J.H.K. and A.J.L., Australian Postgraduate Award awarded to I.C.Z., Baker Foundation Fellowship awarded to D.E.G., NHMRC Peter Doherty Fellowship awarded to C.R.B., NHMRC Principal Research Fellowship (grant number 1020737) awarded to A.J.L., and Australian Research Council Discovery Early Career Research Award Fellowship (grant number DE120100110) awarded to J.H.K. Funding to pay the Open Access publication charges for this article was provided by DE120100110.